Fighting Depression is a health top priority in Portugal, where is still difficult to access effective treatments. Digital treatments for depression aim to facilitate the access to empirically validated treatments. However, one of the major problems in digital treatments for depression is related to the assessment of its clinical efficacy and cost-effectiveness in routine practice, particularly, with its ability to reduce the disease burden. With the current proposal, we intend to respond to these challenges by creating the first form of “combined” computer therapy for depression in Portugal – specifically combining cognitive-behavioral therapy and digital media treatments. We also intend to clarify its clinical efficacy and cost-effectiveness through a clinical trial, comparing, at a clinical and cost-effective levels, the blended cognitive psychotherapy and the treatment usually used in primary healthcare units in the Porto’s area.